Potensi Coriatin dan Coriamyrtin Helixanthera sessiliflora (Merr.) Denser sebagai Kandidat Obat Penurun Hipertensi; Kajian in silico
Kata Kunci:
antihipertensi, coriamyrtin, coriatin, inhibitor ACE, in silicoAbstrak
Penelitian ini bertujuan untuk mengidentifikasi potensi senyawa bioaktif benalu (Loranthaceae) sebagai kandidat obat hipertensi melalui penghambatan angiotensin converting enzyme secara in silico. Senyawa target Loranthaceae yaitu coriatin dan coriamyrtin diunduh strukturnya dari database PubChem NCBI, selanjutnya protein target hipertensi yaitu angiotensin converting enzyme (ACE) yang diunduh dari protein data bank. Lisinopril digunakan sebagai control pembanding inhibitor ACE. Senyawa target dan lisinopril didocking dengan protein ACE dengan molegro virtual docker versi 5.0 dan divisualisasi dengan PyMol versi 2.3 dan Discovery studio versi 21.1.1. analisis docking menunjukkan senyawa coriatin dan coriamyrtin berikatan dengan protein ACE didaerah yang sama dengan lisinopril, dengan residu yang diikat yaitu HIS353. Selain itu beberapa residu coriatin dan lisinopril juga teridentifikasi sama diantaranya GLN281, HIS383, dan TYR520. Residu sisi aktif coriamyrtin yang teridentifikasi di lisinopril antara lain GLU384, GLU411, HIS513, dan HIS387. Residu sisi aktif yang sama antara senyawa target dan lisinopril mengindikasikan bahwa senyawa coriatin dan coriamyrtin berpotensi sebagai kandidat obat hipertensi seperti lisinopril. Penelitian ini disimpulkan bahwa senyawa coriatin dan coriamyrtin yang terkandung di dalam Loranthaceae berpotensi sebagai kandidat obat hipertensi.
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